Teotard represents pure anhydrous theophylline (a xanthine derivative) in the form of granules. Theophylline belongs to inhibitors of phosphodiesterase, increases the accumulation of buy proviron online tissues, which reduces the contractile activity of smooth muscle. The drug has a pronounced bronchodilator effect, prevents or eliminates the bronchial obstruction. Improvement in lung function can increase the oxygen supply of arterial blood, which reduces the concentration . Teotard has a stimulating effect on the respiratory center, reduced pulmonary vascular resistance, lowers blood pressure in the pulmonary circulation, improves mucociliary clearance; It has positive inotropic and chronotropic effects on the heart. The drug stimulates diuresis.Dilates blood vessels (mainly the brain vessels, skin and kidney), utnetaet platelet aggregation. Following oral administration buy proviron online almost completely absorbed.Slow release of the active ingredient from capsules, retard formulation maintains uniform serum levels of theophylline for 12 hours. Bronchodilator effect develops gradually, so the drug is not indicated for the relief of emergency conditions. After a single use of 350 mg of the drug, within 6,3-8,8 hours reached its maximum concentration in plasma, which is 4.4 g / ml. Therapeutic concentration achieved in a few days and it is 8-20 g / ml. Teotard metabolized mainly by the liver microsomal enzymes.
Treatment and prevention of reversible bronchial obstruction in bronchial asthma, chronic obstructive bronchitis, emphysema. Pulmonary hypertension in chronic pulmonary heart. Night breathing disorders of central origin.
: Hypersensitivity to theophylline, pregnancy, breastfeeding, epilepsy, acute myocardial infarction, arrythmia, gastric ulcer and duodenal ulcer in the acute stage, children under 3 years of age.
Prudence and decreasing the dose needed for severe violations of liver and kidney function, as well as congestive heart failure.
Dosage and administration Capsules buy proviron online of the drug can not be opened or chewed. Dosage is individual preparation. Unacceptable exceed a daily dose of 15 mg / kg for adults and 20 mg / kg in children. For the selection of the dose necessary to determine the concentration of theophylline in serum. Typically, the concentration of theophylline in serum from 10 to 15 dg / mL provides a therapeutic effect with minimal risk of side effects. If the concentration exceeds 20 dg / ml, the dose should be reduced. During the first three days should take one capsule retard the drug every 12 hours. On the third day should be to assess the effectiveness of therapy and tolerability of the drug. The dose may be increased in case of insufficient efficacy. In the case of unwanted side effects dose should be reduced. Teotard 200 mg administered to children whose weight exceeds 20 kg, as well as adults with low body weight. Teotard 350 mg is prescribed for adults and children whose weight exceeds 40 kg. Morning and evening dose may be different depending on the time of occurrence of attacks of shortness of breath, the clinical picture of the disease and the effectiveness of therapy.
Disorders of the gastrointestinal tract is buy proviron online rarely observed. Overdose of the drug may cause some patients pain in the stomach, nausea, vomiting, diarrhea, headache, heart rhythm disturbances, tachycardia, decreased blood pressure, increased frequency of angina attacks, insomnia, tremor, irritability, increased diuresis, hyperglycemia, hypokalemia. There are skin rash, itching. In these cases, the dose should be reduced. The incidence of side effects increased if the serum drug concentration exceeds 20 dg / ml.
The drug is not recommended for use in severe hypertension, widespread atherosclerosis. Caution should be used in severe angina, heart failure, severe cardiac arrhythmias, hypertrophic cardiomyopathy, hyperthyroidism, expressed human liver and kidney damage.
In severe diseases of the cardiovascular system, liver, viral infections, as well as in elderly patients the dose should be reduce. Persons who undergoes rapid metabolism of theophylline (young persons, smokers) a single dose of the drug per day will be sufficient.
The interaction with other drugs
Theophylline is not used in conjunction with other xanthine derivatives. In combination with phenobarbital, phenytoin, rifampin, isoniazid, carbamazepine, sulfinpyrazone, a decrease in the effectiveness of phenytoin theophylline, which may require an increase in the applied doses of the drug. While the use of antibiotics macrolide, lincomycin, allopurinol, cimetidine, isoprenaline, oral contraceptives, epoksatsinom and vaccination against influenza may increase the intensity of the action, which may require dose reduction of theophylline. The drug inhibits the therapeutic effects of lithium carbonate and beta-blockers. Theophylline potentiates the effect of diuretics due to an increase in glomerular filtration and tubular reabsorption buy proviron online reduction. With caution is prescribed concurrently with theophylline antikoakulyantami.