After oral completely absorbed into theophylline (bioavailability 90%). At 40-60% blood bound to proteins. It penetrates through the blood-tissue barriers.Biotrasformiruetsya in the liver to inactive metabolites. Excreted mainly by the kidneys, partly in breast milk.
Indications Treatment and prevention of bronchial proviron dosage obstruction in bronchial asthma, chronic obstructive bronchitis, emphysema, dermatorespiratornom syndrome and other respiratory diseases.
Contraindications: Hypersensitivity (including to other xanthine derivatives – caffeine, pentoxifylline, theobromine), acute myocardial infarction, severe arterial hyper- or hypotension, widespread atherosclerosis, serious heart rhythm abnormalities (severe tachyarrhythmias, arrythmia), hyperthyroidism, gastric ulcer and duodenal ulcer in the acute stage, gastritis with high acidity, bleeding from the gastrointestinal tract, epilepsy, increased seizure activity, cerebral hemorrhage, retinal hemorrhage, pregnancy, children under 3 years.
Precautions Caution should be used in severe angina, heart failure, hypertrophic cardiomyopathy, expressed human liver and kidney, gastric ulcer and duodenal ulcer (in history), bleeding from the gastrointestinal tract buy proviron in the recent history of prolonged hyperthermia, gastroesophageal reflux, prostatic hypertrophy.
Dosing and Administration teopeka administered orally after proviron dosage meals with water. The tablet is not crushed, not chewed or dissolved in water. The daily dose is divided into 2 doses 12 hours apart. Optimal dose picked individually, depending on the nature of the disease, the age and the patient’s weight. The drug is administered 2 times a day for adults and children over 14 s 300 mg; Children from 7 to 12 years – 200 mg, 3 to 7 years -. 100 mg on the first day of treatment start with half of the daily dose of 2 admission. If no adverse reactions are moving to a full daily dose. The duration of the drug depends proviron cycle on the characteristics of the disease and to render a therapeutic effect. On average, the treatment course can last from 2 weeks to 2 months.
Side effects of the nervous system : dizziness, headache, insomnia, agitation, anxiety, irritability, tremors. Cardio-vascular system : palpitation, tachycardia (including the fetus when taking pregnant III trimester), arrhythmias, lowering blood pressure, false angina, increase in the frequency of angina attacks. From the digestive system : gastralgia, nausea, vomiting, gastro-oesophageal reflux, heartburn, aggravation of peptic ulcer, diarrhea, Propafenone – decreased appetite. Allergic reactions : skin rash, itching, fever. Other : chest pain, tachypnea, feeling the tides to face, albuminuria, hematuria, hypoglycemia, increased urine output, increased sweating. Side effects are reduced at lower dose.
Overdose. Symptoms : loss of appetite, gastralgia, diarrhea, nausea, vomiting (including blood), gastrointestinal bleeding, tachypnea, facial flushing, tachycardia, ventricular arrhythmia, insomnia, motor agitation, anxiety, photophobia, tremor , convulsions. In severe poisoning can develop epileptic seizures, hypoxia, metabolic acidosis, hyperglycemia, hypokalemia, lowering proviron dosage blood pressure, confusion, renal failure with myoglobinuria. Treatment : removal of the drug, gastric lavage, the appointment of activated charcoal, laxative drugs, intestinal lavage combination of polyethylene glycol and electrolytes , forced diuresis, hemosorbtion, plasmasorption, hemodialysis (efficiency is not high, peritoneal dialysis is not effective), symptomatic therapy (including metoclopramide and ondansetron – vomiting). In the event of seizures, to maintain airway patency and carry oxygen therapy. For relief of an attack – in / diazepam, 0.1-0.3 mg / kg (maximum 10 mg). In severe nausea and vomiting – metoclopramide, or ondansetron (w / w).