Following oral atenolol absorbed from the gastrointestinal tract by 50%. Maximum plasma concentration is achieved 2-4 hours after ingestion. Atenolol proviron cycle does not undergo hepatic metabolism and expressed more than 90% of the absorbed drug is excreted unchanged. The half-life is 6-9 hours, but can be increased in cases of renal insufficiency, because excretion of the drug takes place mainly through the kidneys. Plasma protein binding is approximately -. 6-16%
After ingestion chlorthalidone absorbed from the gastrointestinal tract by 60%, the maximum plasma concentration is observed after about 12 hours after ingestion of the drug. The half-life is about 50 hours, and excretion occurs mainly via the kidneys.
Chlorthalidone binds to plasma protein by about 75%.
At the same time the use of chlorthalidone and atenolol has little effect on the pharmacokinetics of each.
Tenoroks effective for at least 24 hours after single oral daily dose one.
- hypersensitivity to any component of the drug.
- bradycardia; cardiogenic shock; severe hypotension; metabolic acidosis; The expressed disturbances of peripheral circulation; antrioventikulyarnaya block II and III level; sick sinus syndrome;pheochromocytoma; congestive heart failure; chronic heart failure; Prinzmetal angina; bronchial asthma, obstructive bronchitis; diabetes mellitus, hypokalemia; gout; myasthenia gravis; acute hepatitis;acute renal failure
- Children up to age 18 years.
Be wary appoint patients with atrioventricular block I degree, patients with broncho-obstructive syndrome, in case of worsening of bronchial conductivity due to receiving “Tenoroksa” prescribed therapy of beta-agonists (eg, salbutamol). Use during pregnancy and lactation : The use Tenoroksa during proviron cycle pregnancy and breast-feeding is contraindicated.
The impact on participation in road traffic
use of the drug is unlikely to lead to any disruption of the ability of patients to drive or operate machinery. However, it should be appreciated that it may be increased fatigue and dizziness. This effect increases with the simultaneous reception of alcohol.
Dosing and Administration Adults Inside, not liquid, and 1 tablet per day. When hypertension the initial dose is 50 mg of atenolol once a day, in case of insufficient expression of the therapeutic effect appointed “Tenoroks” one pill fort, containing 100 mg of atenolol per day. For the elderly For this age group the dose often require a lower dose of the drug (½ tablet atenolol 50 mg). If the kidney functionCaution should be exercised when treating patients with impaired renal function. Abolition of the drug after long-term treatment that, if possible, gradually.
Tenoroks generally well tolerated. Laboratory findings : Hyperuricemia; hyponatremia (related to chlorthalidone); Hypokalemia:. impaired glucose tolerance (see section “Special Instructions”) Side effects associated with its administration, are rare, in most cases are not severe and temporary. Discontinuation of beta-blockers should be gradual. There were reports of nausea and dizziness in connection with taking chlorthalidone and rarely reported such reactions idiosyncrasies to the drug as thrombocytopenia and leukopenia. on the part of the cardiovascular proviron cycle system : bradycardia; increased symptoms of heart failure; orthostatic hypotension, which may be accompanied by syncope; extremities cold snap. Occurrence of cardiac arrhythmias, including atrioventricular block; symptoms of intermittent claudication, the occurrence of Raynaud’s syndrome. CNS : confusion; dizziness; headache; emotional lability; acute psychosis, hallucinations; paresthesia; sleep disorders, fatigue, lethargy; disorientation. Co gastrointestinal tract : dry mouth; rarely – increased level of “liver” transaminases in blood serum; rarely – liver toxicity with symptoms of intrahepatic cholestasis; nausea (related to chlorthalidone), constipation, diarrhea, pancreatitis, anorexia. Hematologic Reactions : Leukopenia; purpura; thrombocytopenia; agranulocytosis, eosinophilia. With the Skin: alopecia; psoriasiform skin reactions;exacerbation of psoriasis; skin rash. The respiratory system : bronchospasm may occur in patients suffering from bronchial asthma or having in the anamnesis on bronchospasm. From the senses: blurred vision. Other : increase in the number of anti-nuclear antibodies, although the clinical significance of this fact is not clear, reduced potency.