As with other alpha1-blockers, terazosin may cause syncope. Syncope may occur within 1-1.5 hours after the initial dose. In a few cases to syncope can dramatically increase the heart rate tobayer provironAfter the first dose of the drug may develop a pronounced reduction in blood pressure, which can lead to orthostatic dizziness, in severe cases – to fainting. The most characteristic of syncopal episodes that occurred during the period of 30-90 minutes after the first dose, as well as a correlation with a rapid increase in dose, or the use of other antihypertensive therapy.
The incidence of side effects is classified according to the recommendations of the World Health Organization: very often – at least 10% ; often – at least 1% but less than 10%; infrequently – at least 0.1% but less than 1%; rare – less than 0.01% but less than 0.1%; very rarely – less than 0.01%, including isolated reports. From the blood and lymphatic system: very rarely – thrombocytopenia.
On the part of the cardiovascular system bayer proviron: often – fainting (especially when rapid change in body position from the position of “lying” to “standing” or to the “sitting” – postural hypotension), palpitations, tachycardia, chest pain, peripheral edema, very rarely – atrial fibrillation (however, causal relationship with the drug intake has not been established). from the nervous system : often – dizziness, weakness, headache, fatigue, irritability, drowsiness, paresthesia; rarely – depression, syncope. The respiratory system, organs, thoracic and mediastinal disorders: very often – nasal congestion, rhinitis, sinusitis; unknown frequency – shortness of breath. On the part of the digestive system: often – nausea, constipation, diarrhea, vomiting. From the senses: very often – blurred vision, amblyopia; often – reduced visual acuity, impaired color perception; unknown frequency – vertigo. On the part of the musculoskeletal and connective tissue disorders: often – back pain; unknown frequency – pain in the limbs. On the part of the reproductive system:often – erectile dysfunction; infrequently – decreased libido; very rarely – priapism; unknown frequency – impotence.
Allergic reactions: often – skin rash, itching; rarely – urticaria, anaphylactoid reaction. From the urinary system: . often – urinary tract infections bayer proviron and incontinence (primarily in postmenopausal women) Other: . infrequently – weight gain more information on adverse reactions reports were received in the clinical trials and application in clinical practice: flu-like symptoms, upper respiratory tract infection, pharyngitis, urinary tract infection, anxiety, insomnia, conjunctivitis, tinnitus, arrhythmia, vasodilation symptoms, bronchitis, cough, abdominal pain, dryness of the oral mucosa, dyspepsia, bloating, chest pain, neck pain, pain in the shoulder, arthralgia, arthritis, myalgia, increased urge to urinate, urinary incontinence (women in menopause), angioedema, current worsening of gout, nasal bleeding, sweating, fever ; small but statistically significant decrease in hematocrit, hemoglobin, white blood cells, hypoproteinemia, hypoalbuminemia, which may indicate hemodilution. Terazosin treatment for 24 months. no significant effect on the concentration of total and free prostate specific antigen (PSA). A clear communication of adverse reactions with the use of terazosin is not established.
Overdose Symptoms: marked reduction of blood pressure, impaired motor coordination, fainting, disturbances of water and electrolyte balance. Treatment: gastric lavage, the use of absorbent, symptomatic therapy. In marked decrease in blood pressure of the patient is necessary to lay on your back, legs lifted, hold correction . No specific antidote. Hemodialysis is ineffective. If necessary, enter vasopressor drugs, conduct correction indicators of water and electrolyte balance, monitor renal function.
Interaction with other medicinal products
According to the results of clinical trials, concomitant use of terazosin and inhibitors or diuretics angiotenzinprevrayuschego enzyme was accompanied by a greater incidence of symptoms of orthostatic hypotension, and other side effects.
With simultaneous use of terazosin with other antihypertensive drugs may increase antihypertensive action. With simultaneous use of thiazide diuretics or other antihypertensive agents may need to reduce the dose or even a cancellation and re-titration of the dose under medical supervision.
The simultaneous use of terazosin with bayer proviron other alpha-blockers is not recommended due to the increased frequency of symptoms of adverse reactions.
In an application with vasodilators and nitrates can be enhanced antihypertensive effect of terazosin.
Suction terazosin reduced while receiving antacids and adsorbents.
The simultaneous use of the drug terazosin -Teva and PDE5 inhibitors (eg, sildenafil, tadalafil, vardenafil) may be the cause of pronounced reduction in blood pressure.
Non-steroidal anti-inflammatory drugs (especially indomethacin) and estrogens may reduce the antihypertensive effect of terazosin, due to the suppression of prostaglandin synthesis and / or fluid retention and sodium.
Sympathomimetics may reduce the antihypertensive effect of terazosin (risk of hypotension) and reduce the vasodilating effect in response to dopamine, ephedrine, norepinephrine, metaraminol, methoxamine and phenylephrine.
terazosin reduce the antihypertensive effect of clonidine administered intravenously.